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Integrating the Art and Nuance of Ketamine Dosage: A Holistic Approach

As an integrative psychiatrist, I have observed that the effectiveness of ketamine therapy goes beyond the chemical properties of the compound itself. The art and nuance of ketamine dosage play a critical role in the overall experience and success of the treatment.

Six Key Factors Influencing Ketamine Dosage

In my practice, I consider six main factors when determining the ideal ketamine dosage for each patient: age, experience with psychedelics, history of trauma, one's ability to "let go," body weight, and known history of sensitivity to medications. The form I use most in practice is intramuscular (IM) and dosing ranges below are given in that context.

Before diving into these factors, it is important to note that the information provided in this blog post should be used for general understanding and should not replace consultation with a qualified healthcare professional. Always consult with a medical professional before making any decisions regarding your health or treatment.

Age and Ketamine Dosage

A patient's age can influence their metabolism and sensitivity to ketamine. Generally, older individuals may require lower ketamine dosages or slower titration to minimize side effects and maximize therapeutic benefits.

Experience with Psychedelics: Navigating Altered States

Prior exposure to psychedelic substances can impact a person's response to ketamine. Those with previous experience may have a higher tolerance or be more comfortable navigating altered states of consciousness. In such cases, we may consider a slightly higher initial ketamine dosage.

Trauma History: Finding the Right Balance

For individuals with a history of trauma, ketamine therapy can be both powerful and challenging. In these cases, it's essential to start with a lower ketamine dosage to ensure a gentle and supportive therapeutic experience.

One's Ability to "Let Go":

The willingness to surrender and trust the process can significantly impact a patient's response to ketamine therapy. Those who struggle to "let go" may benefit from a more cautious ketamine dosage approach, ensuring a comfortable and secure experience.

Body Weight Considerations

Body weight can influence the distribution and metabolism of ketamine in the body. Therefore, ketamine dosage adjustments may be necessary to account for differences in weight, ensuring an optimal therapeutic experience.

A recent research article by Wilkinson et al. (2021) supports the use of a weight-based dosing framework for ketamine therapy. The study suggests a starting dose of 0.5 mg/kg, with a typical dosage range of 40 mg to 110 mg, depending on individual factors and clinical context. This research highlights the importance of personalizing ketamine dosages to optimize therapeutic outcomes and minimize side effects.

Known History of Sensitivity to Medications:

For patients with a known history of sensitivity to medications, careful attention must be paid to ketamine dosage. It may be necessary to start with a lower dose and adjust gradually to prevent adverse reactions while still ensuring therapeutic effectiveness.

The Ketamine Dosage Spectrum: From Relational Work to Ego Dissolution

In general, it is a common practice to start with a low ketamine dosage to assess a patient's unique response to ketamine. This approach allows healthcare providers to carefully monitor the individual's experience, needs, and goals, and adjust the ketamine dosage accordingly. Ketamine dosage is indeed a spectrum, with lower doses proving beneficial for relational and introspective work, while higher doses can induce profound, transformative experiences that some might describe as akin to "ego dissolution."

The higher ketamine dosages, while potentially more challenging, can facilitate a deep reconnection with oneself and a broader perspective on life. The lower ketamine dosages, on the other hand, can provide a gentler, more grounded experience that fosters personal growth and self-awareness.

As an integrative psychiatrist, my goal is to guide each patient along their unique path, harnessing the full potential of ketamine therapy through a safe, supportive, and personalized ketamine dosage strategy. Remember to always consult with a qualified healthcare professional before making any decisions regarding your health or treatment.

If you're interested in experiencing the transformative power of ketamine therapy for yourself, consider our personalized ketamine retreat packages. These tailored experiences are designed to provide you with the support and guidance needed to make the most of your ketamine journey. To learn more about our retreat offerings and find the perfect package for your needs, visit here. Embark on a path toward healing, self-discovery, and personal growth with our expert guidance and support.


Wilkinson, S. T., Ballard, E. D., Bloch, M. H., Mathew, S. J., Murrough, J. W., Feder, A., ... & Sanacora, G. (2021). The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis. American Journal of Psychiatry, 178(2), 150-158.


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